The phrase "a large determinant" is correct and usable in written English.
It can be used in contexts where you are discussing factors or variables that significantly influence an outcome or result.
Example: "In the study of economic growth, education is often considered a large determinant of productivity."
Alternatives: "a significant factor" or "a major influence".
A robust nutrient gradient, driven mostly by dissolved inorganic nitrogen, from alongshore to offshore in the main Bay, was a large determinant in the spatial clustering.
It seems that what someone is focusing on is a large determinant of whether or not they support the death penalty.
If private equity real estate isn't part of your portfolio, it needs to be; asset allocation is a large determinant of investment success.
In both cities, indoor exposures were a large determinant of cancer risks.
The socialization of children is a large determinant of their future as men, women, husbands, wives and parents.
In Indonesia, Arcari et al. (2007) found that variation in rainfall patterns among provinces was a large determinant of the strength and direction of associations between climate variables and DF incidence.
The sensory capacity of a species was found to be a larger determinant for fish abundance at baited underwater video drops than was the actual density of that species.
The study went on to explain that total sleep, as well as quality of sleep, was a larger determinant of weight loss success than other factors.
Tissue type and cell composition appear to be a larger determinant of the expression profile of such transcripts than the individual from which the tissues were obtained.
These factors made survival a larger determinant of fitness in Norway, favoring selection for longer shoot vegetative stages such as seen in Spiterstulen genotypes.
The presence of work-related respiratory symptoms was positively associated with respiratory sick leave, but time of symptom onset was not, suggesting that having a work-related pattern to respiratory symptoms was a larger determinant of respiratory sick leave than whether the symptoms arose before or after building occupancy.
