The phrase "a large departure" is correct and usable in written English.
It can be used to describe a significant change or deviation from a previous state, plan, or norm.
Example: "The new policy represents a large departure from our traditional approach to employee management."
Alternatives: "a significant change" or "a major shift".
For Facebook that's a large departure from their pre-IPO strategy".
The results showed a large departure from predictions, based on the Standard Model, of the way muons wobbled in a powerful magnetic field, Dr. Kirk said.
The set at Grand Palais included a large departure board featuring the destinations where the brand has held its recent resort fashion shows – from Dallas to Salzburg to Shanghai.
However, for measuring an aspheric surface with a large departure from a perfect spherical surface, both of these methods are difficult to use.
In the meanwhile, expulsion of a group from Friendster for not complying with the regulations resulted in a chain reaction that ended in a large departure of end-users (Ellison et al. 2007).
Bearing in mind that in the past every original ISC hypocentre has been reviewed by ISC analysts, we have decided to review only those new ISC solutions that showed a large departure (50 km and more) from the original hypocentre or large change of origin time ("WITH ISSUES" category shown in Fig. 7).
Comments of this sort make some people believe that a euro exit would be prelude to a larger departure from European and Western alliances, and possibly even a drift toward Russia.
And a few — like Universes, a hip-hop-influenced theater ensemble, and Culture Clash, a Chicano performance troupe, whose play "American Night" will have its world premiere here next season — represent a fairly large departure from the traditional aesthetic at the festival before Mr. Rauch arrived.
In the first scenario that we examine, we set α = 0, γ = 1 and δ = 1 (a relatively large departure from MAR), and in the second scenario, α = 0, γ = 0.8 and δ = 0.5 (a moderate departure from MAR) to achieve approximately 50%% missingness in the outcome Y for each of the 1000 simulated datasets.
Youthanasia was not a large stylistic departure from the band's earlier recordings.
The album is not a large stylistic departure from the band's earlier recordings; however it marked the continuing evolution of Megadeth, following the footsteps of the previous album Countdown to Extinction (1992).
