The phrase "a large defect in" is correct and usable in written English.
It can be used to describe a significant flaw or issue within a particular object, system, or process.
Example: "The engineers discovered a large defect in the software that caused frequent crashes."
Alternatives: "a major flaw in" or "a significant issue in".
Type IV hiatus hernia is associated with a large defect in the phrenoesophageal membrane, allowing other organs, such as colon, spleen, pancreas, and small intestine to enter the hernia sac (Figure 14). Figure 13: Type III paraesophageal hiatal hernia.
By modifying the traditional surgical technique and post-operative care, we were able to design a pedicled fascio-cutaneous ALT flap to cover a large defect in the epigastric region.
The destructive test shows a large defect in area a in this seam section.
We considered that tumor excision was essential to enable adequate wound treatment; this tumor excision resulted in a large defect in the pelvic floor.
Pelvic exenteration results in a large defect in the pelvic floor, increasing the likelihood of internal organs herniating into the infectious wound.
Tumor resection resulted in a large defect in the pelvic floor, increasing the likelihood of internal organs herniating into the infectious wound.
Germans would gain from rectifying this, for example through a much-needed boost to public infrastructure, which has been neglected, and a dose of deregulation to spur private investment.The focus on Germany's surplus in any case misses a larger defect in the euro zone's plethora of reforms.
Our results suggest that a lack of the soxS gene results in a larger defect in resistance to superoxide than the lack of a soxR gene.
Use of a larger-bore needle may have led to a larger defect in the pleura.
Furthermore, the longer occlusion time produced images that showed a larger defect in [C]bicarbonate production.
c During the surgery, a large defect was observed in the left maxillary posterior area due to the ameloblastoma.
