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Generally, a small CV indicates strong agreement among analysts and a large CV indicates strong disagreement.
Both SBC treatments displayed a large CV ranging from 14 to 19%.
Similarly, a large CV range was also observed (18 to 22%).
The PATENTS consensus model calculated a large CV RMSE = 61 °C and an even higher RMSE = 74 °C for the PATENTS and COMBINED subsets respectively.
To further explore potential mechanisms behind this, we report additional relevant data from a large CV meta-analysis of linagliptin trial data.
For example, the approval of antidiabetic agents now often requires a large CV safety trial, 2 creating a substantial barrier to the development of new therapies.
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There are two other methods that can be used in combination with TAMD to compute free energies in a large CV-space: (1) the single-sweep method; and (2) the string method in CVs.
Another observation is that a larger CV always refers to a lower reliability despite the same state sojourn time expectation.
Since in all cases the δ parameter was very low and difficult to accurately estimate [ 6], it exhibited a very large CV; for this reason, only the variability of the other parameters will be discussed.
A major consequence of this fact is that TAMD can handle a significantly large CV-space for conformational exploration, while metadynamics may be somewhat limited.
In a large cardiovascular (CV) outcomes trial (SAVOR) in patients with T2DM and with established CV disease or multiple CV risk factors, saxagliptin neither increased nor decreased CV risk compared with placebo as assessed by the composite end point of death from CV causes, nonfatal myocardial infarction, or nonfatal stroke.
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