The phrase "a large cost of" is correct and usable in written English.
It can be used when discussing significant expenses or financial implications associated with a particular action, decision, or project.
Example: "The new policy implementation comes with a large cost of additional training for all employees."
Alternatives: "a significant expense of" or "a high price of".
That gives Office.com an important edge, since marketing is a large cost of doing business on-line.
Notwithstanding a large cost of self-selection, we found that first impressions were substantially enhanced by profile image selection and these selections were tailored to social networking contexts.
If reduced flux causes a high fitness cost, the result is a large cost of hemizygosity.
However, this study does point out that a large cost of care accumulates and is passed on to someone (tax-payer, insurance company or family) in the process of supporting organs for transplantation.
It is also notable that as a proportion of total costs, the enzymatic process is characterised by a large cost of chemicals (15%), two-thirds of which can be attributed to the cost of enzymes alone.
Also, we find that, on average, those countries with a larger cost of disability devote more social spending to this area, which could be a partial response of countries to the mentioned costs.
The result showed that processivity comes at a large cost in terms of enzyme speed [22].
"The main difference… is that power was a much larger cost of the aluminum industry than of the data centers.
Because cardiac patients were much more likely to be admitted, this is reflected in a much larger cost of treatment value for cardiac compared to respiratory emergency department visits.
This analysis underscores the potentially large costs of a fuel economy standard relative to alternative policies aimed at reducing petroleumuse and GHG emissions.
The letter claimed the proposed legislation "protects Americans from the large costs of an out-of-control subsidy".
