The phrase "a large challenge to" is correct and usable in written English.
You can use it when describing a significant difficulty or obstacle that someone or something is facing.
Example: "The new regulations present a large challenge to small businesses trying to comply with the changes."
Alternatives: "a significant obstacle to" or "a major difficulty for".
That message was echoed by Gen. David H. Petraeus, the commander of the military's Central Command, who told the Senate Armed Services Committee that the lack of progress in the Middle East was a large challenge to American interests.
One of the few street circuits in the series, it is closest to the one in Montreal, because it uses public roads in a temporary setup and provides a large challenge to the drivers as the grip level increases over the weekend as the cars lay down rubber and dust it off.
The benefits for each partner need to be enough to make the consortium worthwhile, which creates a large challenge to the overall process design chain.
It is necessary and will be a large challenge to apply the academic models and algorithms into the real-time operation facing the interruption in the system.
The idea of using low-k materials compared to conventional silica (SiO2) poses a large challenge to the back end processes such as wire bonding.
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a large challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue.
Perhaps there is a larger challenge to the introduction of smart solutions.
Community initiatives therefore face a larger challenge to acquire the necessary resources and knowledge about relevant rules, rights and options, which poses a major constraint.
Others, by contrast, maintain that disobedience in opposition to the decisions of private agents can reflect a larger challenge to the legal system that permits those decisions to be taken, which makes it appropriate to place this disobedience under the umbrella of civil disobedience (Brownlee, 2012 20077).
She sees these efforts as part of a larger challenge to protect the planet.
But the alliance's primary focus has always been to wipe out less radical Syrian rebel groups that pose a larger challenge to Assad because they could be a popular, internationally acceptable alternative to him.
