The phrase "a large challenge in" is correct and usable in written English.
It can be used when discussing significant difficulties or obstacles within a specific context or field.
Example: "Implementing the new software system presents a large challenge in terms of training staff and ensuring a smooth transition."
Alternatives: "a significant challenge in" or "a major challenge in".
We also face a large challenge in rebuilding an efficient, competitive private mortgage market, an area in which commercial bank participation is needed.
Nokia faces a large challenge in terms of stealing market share from competitors, particularly as rival handset makers Samsung, HTC and Huawei prepare to roll out their own smartphones running the same Windows Phone 8 software.
A large challenge in the post-genomic era is to obtain the quantitatively dynamic interactive information of the important constitutes of underlying systems.
This reflects a larger challenge in CHF care where a cultural change is required to increase palliative care awareness and address suboptimal palliative care access [ 18].
"First, as we deal with the aging process-or with any large challenge in life-we need and want sympathy and care.
I went there with him to scout the scene for a possible piece for The New Yorker, and among the people Josh introduced me to was Euell Gibbons, who was teaching students how to survive on nothing but foraged foods — not a particularly large challenge in summer on an island in Penobscot Bay.
Mr. McCain still faces a large challenge from his right in the fall, as many conservatives suspect he isn't really one of them.
"There is going to be a very large challenge in siting all of this energy infrastructure," says landscape ecologist Anne Trainor of Yale University, who is developing the estimates with Joseph Fargione, a science director at the Nature Conservancy in Minneapolis, Minnesota.
A large challenge facing StackSocial is maintaining consistency in users.
However, preparation of peptide antibiotics at a large scale is a great challenge in developing these commercial products.
Our findings, in such a small dataset of twelve subjects, need to be confirmed in a larger challenge study cohort and in a field setting and more detailed analysis of the pathways involved is required.
