The phrase "a large bottleneck" is correct and usable in written English.
It can be used to describe a significant obstacle or hindrance in a process or system that slows down progress or efficiency.
Example: "The project faced a large bottleneck due to the lack of resources, causing delays in the timeline."
Alternatives: "a major obstacle" or "a significant hindrance."
Once a company reaches a certain size, even the fastest dedicated internet connections can be a large bottleneck for transferring data.
If such a bill goes into law, the Deferred Action for Childhood Arrivals program shows how it may work, since the government has been able to get through many applications without a large bottleneck, Singer said.
Subculturing with a large bottleneck may, however, generate a diverse mixture of bacterial cells with divergent traits within the bacterial community.
Interestingly, after propagation with a large bottleneck, the bacteria retained the smooth O-antigen chain-expressing phenotype, even without a final passage in broth, and no inverse selection against O-antigen chain expression had occurred.
After passage with a large bottleneck, the futA locus of all 67:21-derived isolates (50pL 67:21) contained a hybrid of the parental futA and futB sequences (type A-B, Figure 7, Table 2).
By comparing the levels of acquired diversity after the three different modes of subculturing, it is notable that the phenotypes were most stable after in vitro passages using a large bottleneck, as compared to in vitro passage with a small bottleneck or in vivo passage in mice.
After 50 large bottleneck in vitro passages of 67:20 and 67:21, the LPS profiles of the recovered bacterial population appeared unaffected and O-antigen chain length as well as Lewis glycosylation of the subcultured isolates were indistinguishable to the corresponding original wild-type strains (data not shown).
None of the in vitro large bottleneck-derived subisolates revealed any acquired modifications in this region, and were all identical to the corresponding wild-type strains (Table 2).
Intuitively, this represents tagging the untagged region of the image volume with the size of the largest bottleneck leading to it from a more accessible region.
However, larger bottleneck size is not necessarily favorable for Li+ migration.
Nor would it help the county's largest bottleneck, the Hawthorne Circle.
