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Discover LudwigThe phrase "a large and persistent" is correct and usable in written English.
You can use it to describe something that is both significant in size or extent and enduring over time.
Example: "The study revealed a large and persistent issue with air quality in urban areas."
Alternatives: "a significant and ongoing" or "a considerable and lasting".
Exact(21)
Pan, Y. D. et al. A large and persistent carbon sink in the world's forests.
Pan, Y. et al. A large and persistent carbon sink in the world's forests.
There is a large and persistent failure to achieve widespread dissemination of evidence-based practices in child health care.
But since 2007 there has been an "unprecedented collapse" – a large and persistent deficit in first-time buyers.
But in many cases the lack of discussion about who and what music education is for is a large and persistent contributor to this issue.
Yet a large and persistent surplus in the trade balance (or the current-account balance, which includes foreign income) can be the symptom of a distorted economy.
Similar(39)
For one type of example, one could point out that if there was a sufficiently large and persistent majority among the United States electorate, nothing could contain them: they could elect Presidents and legislators who would amend the Constitution and, through those same officials, appoint judges who would interpret the (revised or original) Constitution in a way amenable to their interests.
"It's a very large and persistent anomaly, and it tends to lock these patterns into place," Trenberth said.
2) The conventional CAES can use the air as energy storage medium, and require the air storage system with a large capacity and persistent high-pressure.
Because the adjustment mechanisms in the system were inadequate, a number of countries ran large and persistent imbalances in their international payments.
Many local factors combine to determine where a polynya forms and how large and persistent it is, including ice-sheet topography, shoreline geometry, ocean bathymetry, grounded icebergs and winds24,28.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com