The phrase "a large and influential" is correct and usable in written English.
You can use it to describe something or someone that has significant size and impact or authority in a particular context.
Example: "The organization is known for being a large and influential player in the renewable energy sector."
Alternatives: "a significant and powerful" or "a major and impactful".
Yale is a large and influential investor, with a $29 billion endowment.
Once the chief executive of such a large and influential authority would have been a national figure, opining on matters going well beyond Norwich; striding the big stage.
He was not of those – a large and influential band – who regard the omission from the beatitudes of the maxim "Blessed are the discreet" as a regrettable oversight.
Like New Jersey, Zheijiang is neighbors with a large and influential city -- its main city, Hangzhou, is about 100 miles from Shanghai.
Kaseasbeh is from a large and influential tribe centered in Karak, a province south of Amman, and his people have been staging protests in front of government buildings.
In addition, a large and influential corporate player in the nation's mortgage markets, Fannie Mae, has decided to put its considerable influence to work to establish enforceable industry standards.
Indeed, one of his opponents is a Shiite landlord: Fakhar Imam, a member of a large and politically influential family.
Another potential candidate is Bill McBride, the managing partner of Holland & Knight, a large and politically influential law firm in the state.
The second, a large and extremely influential treatise upon which all the ancient and modern fame of Diophantus reposes, is his Arithmetica.
When people think of PR they generally think of media relations, and of course this is important as it's a way to reach a large, and often influential, audience.
What followed said, "Glenn Beck is a powerful advocate for Israel with a very large and influential audience, and we are proud to have the opportunity to host him in the Knesset Immigration Committee in July".
