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The phrase "a large and efficient" is correct and usable in written English.
You can use it to describe something that is both sizable and effective, often in contexts related to systems, organizations, or processes.
Example: "The company has developed a large and efficient supply chain that minimizes costs and maximizes delivery speed."
Alternatives: "a substantial and effective" or "a big and productive".
Exact(5)
A large and efficient commercial organization tangled with the national government recently and came off badly.
The country already has a large and efficient industry producing ethanol fuel from sugar cane.
The New Yorker, July 29 , 1933P. 7 A large and efficient commercial organization tangled with the national government recently and came off badly.
By B. C. Robbins and Richard Lockridge The New Yorker, July 29 , 1933P. 7 A large and efficient commercial organization tangled with the national government recently and came off badly.
The ground state absorption spectra of N-methylpyridinium esters derivatives of 2-methylbenzothiazole hemicyanine dyes allow a large and efficient matching with the light source emission spectra (argon laser at 514 nm) (Fig. 1).
Similar(55)
In the power vacuum that accompanied the decline of the Holy Roman Empire, a number of large and efficient city-states evolved, all having an unusually potent sense of a separate identity.
The majority of the production will be transferred to a larger and more efficient plant in Springdale, Ohio, the company said.
Significant changes included the installation of current-generation Rolls-Royce BR710 turbofan engines, a larger and more efficient wing, and a fully refurbished fuselage.
A well-funded and resourced adversary, perhaps a state that is trying to break into an area secured with vein authentication, could likely replicate this research on a larger and more efficient scale.
The photocatalytic oxidation of dimethyl disulfide (DMDS), a large spectrum and efficient fumigant, was studied with newly developed industrial Virtually Impermeable Films including a photocatalytic function.
A large-scale and efficient synthesis of fully fluorinated boron hydrides, e.g., icosahedral B12F122-, has been also reported [2].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com