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The phrase "a large and active" is correct and usable in written English.
It can be used to describe a group, community, or entity that is both significant in size and engaged in various activities.
Example: "The organization has a large and active membership that participates in numerous community events throughout the year."
Alternatives: "a sizable and dynamic" or "a substantial and engaged".
Exact(39)
The AAEP is a large and active club at Cornell.
Buildings From the Original Chinatown In the 1880s, Butte had a large and active Chinatown.
THE section of Physiology at the British Association meeting at Toronto was a large and active one.
He maintained a large and active private practice and was one of the country's leading neurological consultants.
Behavioral finance is a large and active field which studies models in which some agents are less than fully rational.
As an EE student, you benefit from being part of a large and active — yet still close-knit — student body.
Similar(21)
Downstairs, Helen Mirren and Alan Bates, as Mrs. Wilson and Jennings, head a large and very active servants' contingent that in finely realized ways manipulates the titled crowd above.
Even after winnowing most of its contents away, Prokofiev was left with 71 solo roles in addition to a large and very active chorus; 13 scenes, each requiring its own set; and a running time of more than four hours.
As a result, Mr. Menendez, who is of Cuban descent, has also been traveling the country campaigning for Democrats, most recently in Florida, a battleground state with a large and politically active Cuban population.
That same year Mr. Murphy married the daughter of New York dairy farmers, in the process acquiring a large and politically active extended family: his wife's cousin is the Republican district attorney in Lake George.
We walk along a footpath through a small wooded reserve, where there is a large, and very active, badger sett.
More suggestions(15)
a large and aggressive
a massive and active
a large and dynamic
a broad and active
a wide and active
a large and enthusiastic
a large and efficient
a significant and active
a large and interactive
a large and reactive
a large and engaged
a large and literate
a generous and active
a large and protuberant
a long and active
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com