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The phrase "a large amount of unknown" is not correct in standard written English.
It can be used when referring to a significant quantity of something that is not known or identified, but it requires clarification or rephrasing for better understanding.
Example: "In the experiment, we encountered a large amount of unknown variables that affected the results."
Alternatives: "a significant quantity of uncertainty" or "a considerable degree of ambiguity."
Exact(4)
Surprisingly, a large amount of unknown genera (15.65 40.44%) was discovered in the GIT from Chinese Mongolian sheep (Fig. 4b).
The authors also address a large amount of unknown sequences present in their data set.
For some genomes LTRharvest was inclined to report sequences made up of a large amount of unknown nucleotide sequence, sequence recorded with Ns in the genome, as retrotransposon like.
Of note, the correlation between transcriptome and translatome (r ∼ 0.77) is still much higher than that between translatome and proteome, confirming that there are a large amount of unknown regulatory steps shaping protein biosynthesis.
Similar(56)
The advent of high-throughput genome scale technologies has enabled us to unravel a large amount of the previously unknown transcriptionally active regions of the genome.
The previous English translation, by J. Sibree, first appeared in 1857 and was based on the defective German edition of Karl Hegel, to which Hoffmeister's edition added a large amount of new material previously unknown to English readers, derived from earlier editors.
Although metabolomics is becoming an increasingly popular technique for studying plant stress responses, one of its main current limitations is the large amount of unknown metabolites that are identified during the analysis.
More sequences and annotation for dedifferentiation and redifferentiation in cotton have to be explored to illuminate the large amount of unknown tags that remain.
Considering the large amount of unknown data which exists in structural biology, efficient powerful tools are needed to investigate, analyze and classify the properties and functionalities of this data.
Although the cause of this inflammatory disorder is still unknown, a large amount of evidence suggests that ulcerative colitis is associated with increased activity of reactive oxygen species (ROS), manganese superoxide dismutase (MnSOD) is a kind of superoxide dismutase (SOD) has been demonstrated to play a key role in the pathophysiology of colitis.
However, and despite the intensive follow up from the trialists to obtain outcome data, there is a large amount of missing data; smoking status is unknown for 1036 of the 1758 participants (59%).
More suggestions(15)
a large amount of unexplained
a large amount of strangers
a large amount of ambiguous
a large percentage of unknown
a large amount of unexplored
a large convoy of unknown
a small amount of unknown
a large protein of unknown
a great amount of unknown
a large fraction of unknown
a large region of unknown
a large pool of unknown
a large number of unknown
a large set of unknown
a large gene of unknown
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com