The phrase "a large amount of modification" is correct and usable in written English.
It can be used when discussing significant changes or alterations made to something, such as a document, project, or system.
Example: "The software update required a large amount of modification to ensure compatibility with the new operating system."
Alternatives: "a significant amount of change" or "a considerable degree of alteration."
A high degree of variability is obviously favourable, as freely giving the materials for selection to work on; not that mere individual differences are not amply sufficient, with extreme care, to allow of the accumulation of a large amount of modification in almost any desired direction.
Darwin described this explicitly in the Origin (Darwin 1859, p.40 41): A high degree of variability is obviously favourable, as freely giving the materials for selection to work on; not that mere individual differences are not amply sufficient, with extreme care, to allow of the accumulation of a large amount of modification in almost any desired direction.
Remarkably, a large amount of polymorphism and structure modifications, indicating intrapopulational polymorphism with not all accessions having an identical genomic structure, was observed using GISH [ 6, 19, 20] and C-banding [ 22- 24] techniques.
Thinopyrum intermedium is a species possessing a large amount of cytogenetic polymorphism and structural modifications of chromosomes, with not all accessions previously studied having identical genomic structure [ 20, 22- 24].
However, repeated modifications and a large amount of experimental data are necessary for the parameter identification.
An ultimate secondary battery of sixteen 5 /38 in dual mounts, sixteen Bofors 40 mm in quadruple mounts and eight single Oerlikon 20 mm was called for by the board in 1941, although they were not certain the ships could handle the added weight and it would take a large amount of time in dry dock for these modifications to take place.
Spacers have been developed through empirical modifications, so that a large amount of test data are required for optimum design of the spacer.
As shown for Distalless, introns in the "regulation of transcription" GO category often had a large amount of CG methylation in addition to the non-CG modifications.
However, a large amount of genes involved in cell membrane biogenesis and cell wall modification was determined to be highly down-regulated, specifically in root and young panicle.
Continuous cardioplegia infusion appears an ideal modification to overcome this issue, except for a large amount of crystalloid solution infused into the myocardium.
With the increasing popularity of ChIP-seq technology, a large amount of data in the form of genomic intervals is generated to represent protein binding or histone modification regions under different biological contexts.
