The phrase "a large alteration" is correct and usable in written English.
You can use it when referring to a significant change or modification in a context such as design, plans, or documents.
Example: "The architect proposed a large alteration to the original blueprint to accommodate the new requirements."
Alternatives: "a significant change" or "a major modification."
The ammonia pressure in tank B showed a large alteration after the second measurement.
The reduction in total neurotransmitter release indicated by the aldicarb assay results could be the result of a reduction in the total number of vesicle fusion events at the neuromuscular junction or a consequence of a large alteration in quantal size.
After infection by M. acridum, a large alteration in the transcriptome of the locust fat body was seen, with 4660 genes up-regulated and 1674 genes down-regulated.
The proportion of large genetic alterations that followed repair of irradiation-induced damage might be higher than that observed in this study because a large alteration affecting an essential gene might not be transmitted to the M2 generation [ 39].
Thus, both the UKPDS and DCCT (large, prospective, multicenter, clinical studies) documented that a small change in HbA1c values translates into a large alteration in the risk of diabetes complications in patients with type 1 or type 2 diabetes.
Our results further provide additional evidence supporting that plants could obtain enhanced tolerance to freezing temperature when they undergo CA process, and that the acquired resistance may be attributed to a large alteration of global patterns of gene transcription in CA process.
No one knows exactly how higher average temperatures will translate into, say, changes in precipitation, but, considering that there are more than six billion people on the planet, it wouldn't take a very large alteration to create very significant problems.
The results exhibited that L-NAsp PE surface could preserve most of the secondary structures of immobilized enzymes while on D-NAsp PE surface with a large conformation alteration.
Our data show the presence of a large complex alteration in MCF-7 at 17q21.32-q24.3 with a high-level amplification at 17q23.2.
Table 2 shows the age at breast cancer diagnosis, the details of the tumour morphology and the family history details of the young women found to carry a large genomic alteration in BRCA1 from both the population-based and clinic-recruited families participating in the BCFR.
The dietary comparison revealed large alteration in gene expression in all the tissues studied between fish on the two diets.
