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The phrase "a large age dependence" is correct and usable in written English.
It can be used when discussing how certain factors or outcomes vary significantly based on age.
Example: "The study revealed a large age dependence in the effectiveness of the treatment, with older patients showing different results compared to younger ones."
Alternatives: "a significant age correlation" or "a strong age relationship".
Exact(1)
There is a large age dependence to the acute toxicity of pyrethroids in which neonatal rats are at least an order of magnitude more sensitive than adults to two pyrethroids.
Similar(59)
A large aging population also indicates a smaller labor supply.
A large dependence of S on doping is observed.
Under the constant mortality assumption, control of survival reduces the life expectancy of all mosquitoes by a large amount (Figure 3D); when age dependence is allowed, the reduction in life expectancy was less dramatic and skewed towards younger age classes (Figure 3E).
The age range of the monkey and baboon samples was not sufficient to justify an analysis of age dependence.
The present study additionally points to an age dependence for the development of anti-CCD IgE.
The figure shows a large dependence by TDS, and a low dependence by MDSBA.
Experiments performed with varying protein concentration showed a large concentration dependence on the HbS fibre aggregation.
A longitudinal study of the age dependence of human ocular refraction II.
The strongest evidence of this age dependence comes from two large studies – the atomic bomb survivors Life Span Study and the Childhood Cancer Survivors Study.
Also, a possible effect of cigarette smoking and age dependence were studied.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com