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In short, fluviokarst is a landscape of active stream valleys, dry valleys, blind valleys, and deranged drainage systems.
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In particular, experimental results obtained by chromatin immunoprecipitation (ChIP), FAIRE, and DNase I footprinting assays in combination with high-throughput sequencing have unmasked what was previously a hidden landscape of active DNA regions (Rhee and Pugh, 2011; Furey, 2012; Neph et al., 2012).
Furthermore, the promising results from novel immunotherapies are likely to complement the landscape of active compounds for HCC and will require a completely different approach to patients, as well as the development of prognostic/predictive biomarkers.
Most important, epigenetic marks were erased and rewritten, resetting the landscape of active and inactive genes.
Thus, deciphering the normal epigenetic landscape of active and silenced regions of the genome is important for understanding the changes occurring with disease.
We experimentally dissected the evolution of regulatory regions in mammalian liver by mapping the genome-wide landscape of active promoters and enhancers from 20 diverse species.
To test this, we examined the distribution of ground-active beetles in a landscape of remnant Eucalyptus open woodland patches where large areas of lower contrast matrix (farmland) are being transformed to high-contrast pine plantations in south-eastern Australia.
This painting is a landscape of sorts.
It was a landscape of concrete.
A landscape of statistical genetic interactions.
Move to a landscape of dormant volcanoes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com