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The phrase "a lack of significant" is correct and usable in written English.
It can be used when discussing the absence of something that is important or noteworthy in a particular context.
Example: "The study revealed a lack of significant evidence to support the hypothesis."
Alternatives: "an absence of substantial" or "a deficiency of important".
Exact(59)
None of the French actors who spoke to the Observer complained of a lack of significant roles for women in Gallic films, a frequent lament across the Atlantic.
A lack of significant economic news and the closing of bond markets for the Columbus Day holiday also contributed to the lackluster activity.
The story from here on is limited in some instances by a lack of significant works by major artists, or any works at all.
The sites are a response to a lack of significant leaks since WikiLeaks' release of State Department cables last year, Anonymous said.
There's an oversupply of coverage and a lack of significant experimentation of approach.
Mouse models have not been useful because of a lack of significant response to oxidative challenge.
Both methods indicated a lack of significant quantities of viable cells 14 days after transplantation.
A lack of significant difference between populations is often misinterpreted as demonstrating equivalence between the populations.
A lack of significant difference in cytokine expression between genders is similar to the findings of Linge and Linge [3].
A small sample, uneven cell sizes, and variability of patients might have contributed to a lack of significant findings.
Given its relatively restrictive legislation and generally unfavorable political situation and regulatory framework, there has been a lack of significant foreign investment.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com