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The phrase "a lack of efficacy" is correct and usable in written English.
It can be used when discussing the ineffectiveness or insufficient performance of a method, treatment, or intervention.
Example: "The study revealed a lack of efficacy in the new drug compared to the existing treatment options."
Alternatives: "an absence of effectiveness" or "a deficiency in efficacy."
Exact(60)
Patients who discontinue because of a lack of efficacy may enrich the pool of patients for whom the drug is efficacious.
Another 2015 review cites "inconsistent/weak evidence" for flossing and a "lack of efficacy".
However, in clinical trials high affinity inhibitors of CCR2 have often demonstrated a lack of efficacy.
We and others have argued that the limited clinical trial signal does not reflect a lack of efficacy, but instead a limited mechanistic understanding4,5,6.
In addition, we report a lack of efficacy by unmetallated ATSM in the same model using the same standardized study design.
The main reason for this drug failure rate was a lack of efficacy observed in clinical trials of drug candidates that showed great promise in drug discovery.
A lack of efficacy in gene therapy wasn't the worst problem.
Following enrollment of 20 patients, this study was terminated due to a lack of efficacy.
Antonaci et al. [31] reported a lack of efficacy of sumatriptan in 7 patients.
Ultrasound, while less invasive, suffers from a lack of efficacy compared to these established techniques and also requires specialist equipment.
Finally, in 18 cases (15.7%) OnabotA therapy was interrupted beyond first year due to a lack of efficacy.
More suggestions(16)
a lack of impact
a lack of adequacy
a lack of performance
a lack of validity
a lack of efficiency
a lack of effect
a lack of trials
a lack of cost effectiveness
a lack of therapeutic
a lack of effective
a lack of efficient
a predictor of efficacy
a lack of solidarity
a suggestion of efficacy
a hierarchy of efficacy
a lack of bookkeeping
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com