Patients who discontinue because of a lack of efficacy may enrich the pool of patients for whom the drug is efficacious.
Although third-generation P-gp inhibitors were significantly efficacious in vitro, these compounds are not used clinically because in vivo and preclinical studies indicated a lack of efficacy and/or significant adverse effects [ 46].
Therefore, it is not surprising that ALDH2 ∗ 2 allele is associated with a lack of an efficacious clinical response to nitroglycerin treatment for coronary heart disease [ 44].
These patients have a very poor prognosis because of the lack of efficacious therapy options.
This is in accordance with findings of other studies, 26, 27 where only 15%30%% of patients admitted for MI were taking statins before their event, but with 37.9% of patients with a previous hospitalization for CV reasons, this emphasizes the lack of efficacious primary and secondary prevention of CV disease.
Given a lack of clarity regarding the most efficacious intervention against CIN, a large, multicentre randomised control study has started recruiting (target 8,680 patients, the prevention of serious adverse events following angiography (PRESERVE) trial [ 11]), the results of which will hopefully help to clarify optimal preparation of patients at risk of CIN.
A barrier to the empirical treatment of cough is the lack of efficacious therapies targeting afferent hypersensitivity.
Consequently, in view of the evidence supporting the expression of VDRs in hepatocellular cancers, and the lack of efficacious systemic therapies in this disease, a phase II study was performed in patients with inoperable hepatocellular cancer to determine the objective antitumour activity of Seocalcitol in this disease.
For advanced stage mucinous LMPs, earlier detection of a recurrence may not always result in improved prognosis, due to the lack of efficacious chemotherapy (Tamakoshi et al, 1997).
