For the first time in almost three decades there will be no million-album-selling artist in the UK in 2013, barring the very unexpected, as a lack of breakthrough records and the rise of streaming services such as Spotify hit sales this year.
Beset by piracy, CD-burners and a lack of breakthrough acts, music sales have declined worldwide for three straight years.
There was a lack of true breakthrough titles to follow Akira, which eventually grossed $80m globally.
Leicester continued to see plenty of ball in the Wasps 22, but their frustration at a lack of a breakthrough was summed up when Williams hurriedly belted a drop goal wide of the posts.
I think the failure of this portion of the Internet experience to advance in any meaningful way is not due to a lack of a breakthrough method, but a higher-order problem: no one is challenging the fundamentals of discussion on the Internet.
Mark Fishman of Novartis, a Swiss company, says that after a similar lack of breakthroughs in genomics "we've gone back to the brute-force method of screening millions of candidates that kill a bug and then evaluating them for safety in humans".There are signs that the pipeline at the larger firms is running dry.
Dr. Sidney Wolfe, director of health research for the consumer advocacy group Public Citizen, said that although the entire industry had suffered from a decline in productivity, Pfizer's lack of breakthroughs was notable given its research budget.
A positive result for the presence of HIV-1 from any treated animal by any method indicated a lack of protection referred to as "breakthrough" infection.
"The absence of strong public government leadership contributed to the lack of breakthroughs against terrorists" in Greece, the State Department said in its annual terrorist report.
Like many experts in the field, those at Jet believe the Lockheed announcement is not a breakthrough but a lack of concrete information is frustrating the scientists.
