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Exact(2)
Because only exact algorithms guarantee optimal alignments, there is a lack of a method for verifying results on genome scale.
There was also a lack of a method that would be able to predict resistance caused by a previously unseen mutation.
Similar(58)
This is a result of the poor understanding of the chemistry involved and a lack of a rigorous method of modelling, design and scale-up.
There is a lack of a universal method of measurement suitable for the different attributes of the components.
However, there is a lack of a proven method to assess the precision of the test results of the chamber system.
The major problem in applying SVR and ANN is a lack of a specific method to specify some parameters such as ε and ϒ in SVR and the number of hidden layers in ANN.
I think the failure of this portion of the Internet experience to advance in any meaningful way is not due to a lack of a breakthrough method, but a higher-order problem: no one is challenging the fundamentals of discussion on the Internet.
Up until now, there was a lack of a suitable method that could both quantify and locate microorganisms in a biofilm in a reliable way.
It was challenging to find a starting point due to a lack of a comparable method.
We believe one reason for this may be a lack of a simple method to measure ligament balance during surgery.
However, the underlying molecular mechanisms have been poorly investigated, leading to a lack of a diagnostic method and effective therapy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com