The phrase "a known difficulty" is correct and usable in written English.
It can be used when referring to a challenge or problem that is recognized or acknowledged by others.
Example: "The team is currently addressing a known difficulty in the software that has been affecting performance."
Alternatives: "an acknowledged challenge" or "a recognized issue."
Further, writing test items at higher cognitive levels is a known difficulty (Crooks, 1988).
Determining the correct end points of segments is a known difficulty while identifying segments, and IBD detection at the end of chromosomes is lower.
First, repetitive DNA is a known difficulty for assembly of short sequences into contigs, and the prevalence of retrotransposon sequences could contribute to assembly difficulties.
A test with an unaltered exercise intensity was chosen for this study because of the common use of beta blockers and/or anti-depressants in FM, which may affect heart rate, and since there is a known difficulty in FM in increasing the resistance on an ergometer bicycle [ 16].
Fibreoptic intubation has long been considered the gold standard intubation technique in patients with an anticipated or known difficulty airway or as a rescue device in failure to intubate but able to ventilate scenarios [ 1].
Nevertheless, the main application of the Rasch analysis techniques has been to create banks of items of known difficulty from which tests can be constructed such that candidates of a certain standard of mastery consistently achieve a passing score while others below that level consistently do not (Alderson et al. [1995]).
This finding points to the known difficulty to control cardiometabolic conditions because of insulin resistance [ 61], a situation that should likely result in an increased burden of diabetes-related complications.
Pure must have been aware of this known difficulty.
Finally, the MGO quenching reactivity and the unselective (and unwanted) pyridoxal quenching are found to be influenced by the same parameters thus rationalizing the known difficulty in the design of potent and selective quenchers towards β-dicarbonyls.
Once again, this finding supports gravy index result and likelihood is due to the known difficulty to extract membranous proteins because of its hydrophobic nature.
We reasoned that this observation may be due partly to the nonlethality of the PvdQ knockout and the known difficulty of small molecules to effectively permeate P. aeruginosa.
