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The phrase "a key work in" is correct and usable in written English.
It can be used to refer to an important piece of literature, art, or research within a specific field or context.
Example: "Shakespeare's 'Hamlet' is considered a key work in English literature that explores themes of madness and revenge."
Alternatives: "an important piece in" or "a significant contribution to".
Exact(10)
The book became a key work in later Jewish mysticism.
This is a key work in the actor's repertoire of sullen grumps, as well as one of the more adventurous biopics of recent years.
An Unnatural Pursuit and its successor, How's That for Telling 'Em, Fat Lady? (1988), were both written during, and mostly about, the production of a play - the same play, The Common Pursuit (1984), a key work in Gray's oeuvre.
A key work in musique concrete - where industrial and traffic noises, natural sounds and voices were tape-recorded and then altered by re-recording them backwards at different speeds and with different effects - this is, in essence, fantastically odd electronic experimentalism, which, in 1968, was a hell of more difficult to realise than it is now.
With Berio's Thema (Ommagio a Joyce) (1958) there is also a key work in the development of electro-acoustic music.
The reputation of Don't Look Now has grown since its release and it is now regarded as a key work in horror cinema.
Similar(48)
The first film to utilize surrealistic production design in a major way, Caligari is a key work of the Expressionist movement in post-World War I Germany.
A key work is Portal to a Mosque in a Berlin collection, a graph-paper fantasy summoning up memories of Mamluk glasswork.
Key work in these three areas is described.
However, there is a key factor working in favor of Republicans holding their fire that didn't exist before the elections.
The group will also include a number of key officers working in human resources/organisational development and primary care at local, regional, and national level to provide a link to policy forums and a wider perspective.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com