Sentence examples for a key substrate for from inspiring English sources

The laminin-rich Matrigel reconstituted basement membrane matrix is a key substrate for differentiation of mammary epithelial cells into spherical duct-like structures in culture.

It was recently identified a key substrate for inflammatory caspases called gasdermin D62,63, which upon its cleavage drives pyroptosis and is responsible for membrane pore formation, one of the most important events during pyroptosis.

Maladaptive plasticity within the dorsal horn (DH) of the spinal cord is a key substrate for development of neuropathic pain following peripheral nerve injury.

Coarse woody debris is a key substrate for forest biodiversity, particularly because it undergoes complex succession reflecting the effects of changes in both forest structure and substrate characteristics.

GLN is a key substrate for the hexosamine biosynthetic pathway (HBP), which has been shown to induce HSP70.

Moreover, although there is some discrepancy in the literature [56], [57], increased cellular acylCoAs, specially palmitoylCoA, a key substrate for SCD1 and likely elevated in SCD1 deficient cells [19], was linked to greater levels of catalytically active AMPK in several tissues [26], [58] [60].

SAM serves as a precursor of nicotianamine, for which a role in metal ion homeostasis through chelation mechanisms has been reported [ 50, 51], and as a key substrate of certain methylases for the regeneration of GSH [ 52, 53].

The potent anticoagulant thrombins W215A and W215A/E217A (missing a key substrate platform for binding fibrinogen) were best able to hydrolyze FXIII F34 and W34 APs.

43 Mevalonic acid is a product of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and used to synthesize 5-carbon isoprenoid units that are linked together to generate farnesyl-PP, a key substrate precursor for biosynthesis of cholesterol, dolichols and coenzyme Q.

Using human γD-crystallin (HGD), a key substrate protein for parent α-crystallin in the ocular lens, we show here that MAC not only protects HGD from aggregation during thermal and chemical unfolding but also binds weakly and reversibly to HGD (Kd ≈ 200 700 μM) even when HGD is in the native state.

Since HCO3− is an important key substrate for decarboxylating enzymes involved in various biosynthetic pathways, it has been hypothesized that the lack of CA activity might affect the acetyl-CoA carboxylase dependent biosynthesis of fatty acids [16], [31].