The US's inability to back threats with tangible actions in response to Iran's nuclear trickery has cost America a key non-proliferation tool and suggested the waning of a global power.
Inaction in the face of Iran's defiance of US demands has weakened Washington's foreign policy standing and caused the loss of a key non-proliferation instrument, namely having a credible, and therefore usable, threat against Iran.
We next investigated the signalling pathways involved in CX3CL1-mediated proliferation, initially focusing on extracellular signal-regulated kinase (ERK): a serine/threonine kinase known to be a key regulator in proliferation, survival, and differentiation.
Estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer.
The insulin-like growth factor-1 receptor (IGF-1R) plays a key role in proliferation, growth, differentiation, and development of several human malignancies including breast and pancreatic adenocarcinoma.
These findings emphasize that even A-type potassium channels may play a key role in proliferation and survival of immature progenitor cells.
These results indicate that voltage-activated A-type currents generated predominantly by Kv4.2 channels are likely to play a key role for proliferation and survival of hNPCs.
This study identified LN as a key site for proliferation.
Notch signaling is a key mediator of proliferation, survival, and possibly malignant invasion of TNBC.
MEK1 can activate the transcription factor ERK, a key activator of proliferation signals [ 39].
