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The phrase "a key problem with" is grammatically correct and can be used in written English.
Example: "A key problem with the current education system is the lack of resources for students with learning disabilities."
Exact(26)
That's a key problem with most disaster planning.
The column clearly identifies administrative costs as a key problem with the U.S. system.
Sally Hunt General secretary, University and College Union There is a key problem with the proposed further marketisation of universities and the TEF.
The latter can quickly induce nausea if the scene isn't redrawn quickly enough as the body's balance system disagrees with what the eyes tell it they're seeing; that was a key problem with early VR systems.
A key problem with S.I.P.C. liquidations, some securities lawyers say, is that trustees overseeing the cases have allegiance to the corporation that appointed them, rather than to wronged investors.
They reported that their wire could carry twice as much current as models made at other universities, which helps address a key problem with the nanowire paradigm: the wires are so thin that their current dissipates.
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University residential colleges emerge as a key problem area, with alcohol consumption contributing to sexual assault at college and at university social events more broadly.
27 A key problem encountered with anti-infectives is that the rationale for usage and proposed course of treatment is often poorly documented.
A key problem they struggled with concerned the relation of the form characteristic of the minima of combining substances and the form of the minima of the resulting compound.
However, a deficiency of current IGRAs is that, like TST, they do not discriminate active from latent infection, a key problem in cases with uncertain clinical symptoms or smear negative sputum samples, like extra-pulmonary TB cases (Chegou et al., 2011).
In the particular case of ADL monitoring, an important field of research is the development of effective solutions able to recognize deterioration in movement, help in rehabilitation, and detect accidents, being the identification of falls a key problem to cope with.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com