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Our data suggest that ceramides directly regulate a key initiation step in apoptosis: mitochondrial outer membrane permeabilization (MOMP).
To examine the application value of our promoter microarray design for transcription factors we studied TATA-binding protein (TBP), a key initiation factor that is known to bind to promoter regions.
They proposed that the thickening of the subchondral bone plate, resulting from repeated healing of microfractures, could be a key initiation factor in cartilage degradation.
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The impairment of the endothelium is a key factor driving the initiation and progression of different manifestations of heart disease [ 1].
ORCA, a key player in the initiation of DNA replication, associates with multiple components of the pre-replicative complex (Shen et al., 2012).
This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2).
These regions truly represent promoters as shown by binding of TBP, a key transcription initiation factor.
[ 3] Similarly, earlier work in Pakistan has identified surveillance as a key to initiation and implementation of a successful injury prevention program [ 8, 9].
This may be a key to initiation of the response to B. anthracis and a possible target for enhancement of cellular defenses against this pathogen.
In fact, many studies have shown that LPO products play a key role in the initiation and progression of fibrosis in different organs [ 50].
Dendritic cells (DC) play a key role in initiation of immune responses.
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