Sentence examples for a key initiating factor from inspiring English sources

However, any approach to modulate macrophage phenotype should be an adjunct to existing treatments of lowering lipids, for lipid deposition in the arterial wall is a key initiating factor in atherosclerosis and itself increases the inflammatory nature of the plaque, which could counteract efforts to promote a less inflammatory environment.

Thus, although loss of the Pten tumor suppressor and increased PI3K pathway signaling is a key initiating factor in tumorigenesis, it appears that additional cytogenetic or epigenetic events must occur prior to the development of the PIN lesions as observed at later stages in our mice (Figure 1B).

Wnt5a is a key initiating factor in the non-canonical pathway, but its role in cancer is not known.

With this landscape, infections at the level of the vasculature may be a key initiating factor in the pathogenesis of neurodegenerative diseases such as sporadic AD.

They demonstrated significantly less lung injury in TNF-α-deficient mice after 1 hour of ischemia and 1 hour of reperfusion, suggesting that TNF-α is a key initiating factor in acute lung injury [ 18].

This result may be of particularly important significance in that it may help to further our understanding of how DM induces myocardial apoptotic cell death, a key initiating factor for the development of diabetic cardiomyopathy.

We also show that the mRNA levels of receptor activator of nuclear factor κB (RANK), the key initiating factor and osteoclast associated receptor for RANKL, were potently suppressed by RA in osteoclast progenitors.

The development of ILD associated with anticancer agents is considered to be a multistep process, although one of the key initiating factors is likely to be the apoptosis of non-neoplastic type I and II pneumocytes.

Injury is one of the key initiating factors for OA development (Bhosale and Richardson 2008).

It indicates that Psoriasin is a mediator or a factor involved in the adhesion, rather than a key factor or an initiating factor.

Subcutaneous adipocytes may not have a direct impact on metabolic dysfunction, but they still may play a key role as the initiating factor in the process of fat overflow to ectopic sites.