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The phrase "a key drawback that" is correct and usable in written English.
It can be used when discussing a significant disadvantage or limitation related to a particular subject or situation.
Example: "A key drawback that many users face with this software is its steep learning curve."
Alternatives: "a major disadvantage that" or "a significant limitation that".
Exact(1)
A key drawback that is not well understood is the costs associated with leasing space in a mall or converting an underperforming mall into a healthcare space.
Similar(59)
CML is a low-level formal language, of which a key drawback is that SysML models when mapped to CML results in huge unintelligible descriptions (it was one of the lessons learned from COMPASS) [8].
A key drawback to association mapping is that the large population size required for successful identification of trait markers requires that phenotyping the plants be done in a high-throughput manner which requires a large labor force or robotics.
A key drawback of ranked retrieval is that the size of the result set is likely to be much larger than that returned as the result of a Boolean search strategy.
However, a key drawback of the approach is that it is ultimately static.
A key drawback in heuristic clustering techniques is that it is difficult to determine the number of clusters a priori.
A key drawback of this process is Zn volatility, which requires that Zn vapor be separated from O2.
But electricity has a key drawback as an energy carrier.
For instance, a key drawback to conventional methods of determining phage phylogeny is the necessity of whole genome sequence.
But the invention had a significant drawback that was imposed by quantum mechanics.
For some starry-eyed connoisseurs, that's a drawback that casts them back to their fantasies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com