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The phrase "a key difference between" is correct and usable in written English.
It can be used when discussing distinctions or contrasts between two or more subjects, concepts, or items.
Example: "A key difference between cats and dogs is their social behavior; cats tend to be more independent while dogs are more social and loyal."
Alternatives: "a significant distinction between" or "a major contrast between".
Exact(60)
A key difference between these different metrics is the method used to calculate the IC.
There's a key difference between Nabokov and Sheldon.
But there's a key difference between Kaepernick and Reid.
We see a key difference between the reinsurance and the shareholder risk.
But there is a key difference between the way we teach science and religious teachings.
The meanderings get more twisted when we consider a key difference between Google and Apple.
But Democrats say there's a key difference between liberals and conservatives online.
But there's a key difference between this airport scenario and most like it.
However, there is a key difference between genetics and climate change.
The sculpture illustrates a key difference between Duchamp and Mr. Johns.
This is where a key difference between tokens and traditional equity comes into play.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com