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The phrase "a key challenge in" is correct and usable in written English.
It can be used when discussing significant difficulties or obstacles within a specific context or field.
Example: "A key challenge in implementing new technology is ensuring that all employees are adequately trained."
Alternatives: "a major obstacle in" or "a significant difficulty in".
Exact(60)
Scene understanding remains a key challenge in computer vision.
Image recognition is a key challenge in artificial intelligence.
Finding target paths is a key challenge in path testing.
Intra-patient variability is a key challenge in cancer treatment.
The selective oxidation of methane to methanol is a key challenge in catalysis.
Effectively implementing multimedia applications on multiprocessor architectures is a key challenge in system-level design.
A key challenge in human computation is the effective and efficient coordination of problem solving.
A key challenge in precision medicine lies in understanding molecular-level underpinnings of complex human disease.
"The issue of price will clearly remain a key challenge in future for sellers".
Identifying regeneration initiation signals remains a key challenge in regeneration research.
Creating biological interfaces between mechanically dissimilar tissues is a key challenge in complex tissue engineering.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com