The phrase "a key alteration" is correct and usable in written English.
It can be used to refer to an important or significant change in a particular context, such as a process, document, or system.
Example: "The report highlighted a key alteration in the company's policy that would affect all employees."
Alternatives: "a crucial change" or "a significant modification".
Dickey credited Hough, a former knuckleballer, with making a key alteration to his throwing grip after the two met for the first time in 2005.
This is a key alteration in homeostasis since the stroma is normally restricted from access to proteins secreted by epithelium into the lumen within glandular tissues.
Hyperglycaemia induces oxidative stress which increases profibrogenic factors leading to interstitial fibrosis, a key alteration in diabetic cardiomyopathy.
Increased glucose uptake is a key alteration associated with the high glycolytic rate of cancer cells (the Warburg effect) [ 5], and reprogramming of energy metabolism can now be viewed as one of the "hallmarks of cancer" [ 6].
20 Common to most of these entities are: loss of SMARCB1 as a key alteration, rhabdoid cell component that varies from subtle (represented by a few scattered cells) to extensive comprising almost 100% of the neoplasm, and a frequently (but not obligatory) aggressive clinical course with widespread metastasis at time of diagnosis.
Gaga's rendition of The Star-Spangled Banner had one key alteration: as the a cappella number reached its apex, she changed a lyric to refer to the rainbow flag: "Oh, say does that star-spangled flag of pride yet wave/ O'er the land of the free and the home of the brave".
Metabolic acidification is a key cellular alteration in a number of clinically important situations including the cardiac ischaemia that occurs with acute coronary artery occlusion.
MC: What are some of the key alterations a woman should be looking to make?
This work clearly shows the importance of stratification into tumor subtypes, followed by a focused assessment of key alterations and/or pathways.
It should be noted that such a model does not suggest the presence of regulatory 'master-switches' but rather the re-balancing of a complex system in response to key alterations.
Thus, pinpointing the key alterations (driver mutations) from a background of variations with no direct causal link to cancer (passenger mutations) is difficult.
