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A: Indonesia, Singapore and Malaysia are conducting a search-and-rescue operation near Belitung island in the Java Sea, the plane's last known whereabouts.
H5 from Indonesia strain (A/Indonesia/CDC669/2006) was used as backbone sequence.
A 10% seroconversion rate was recorded in the same subjects for the recombinant subclade 2.1 A/Indonestrain2005 strain.
A H1N1 virus (A/WSN/33, WSN) and a H5N1 virus (A/Indonesia/5/05, Indo5) were used as the prototype strains in the study.
Immunization with HA derived from the A/Indonesia/05/2005 strain or set 1 of the 5 component multivalent DNA vaccine showed a survival rate approaching 90%.
Interestingly, all animals without a detectable neutralizing antibody response to A/Vietnam or to A/Indonesia exhibited lung virus load > 8×103 tissue/g tissue, whereas 94% (16/17) of ferrets with anti-A/Vietnam neutralizing antibody response and 93% (13/14) with anti-A/Indonesia responses showed virus loads in their lungs below 102 tissue/g tissue.
The H5N1 candidate vaccine adjuvanted with AS03A elicited a strong and persistent immune response against the vaccine strain A/Indonesia/5/2005 in Japanese adults.
The vaccine contained 7.5 μg of wild type strain A/Indonesia/05/2005, which was a clade 2.1 influenza A H5N1 virus strain.
Shoji et al. [ 8] expressed a truncated version of plant codon-optimised HA from H5N1 (A/Indonesia/05/05) in N. benthamiana plants.
Reverse cumulative distribution curve of the HI response after the second dose of immunization showed similar HI response in the control group and A/Indonesia/05/2005 primed group, but a higher HI response in A/Vietnam/1194/2004 and A/Indonesia/05/2005 primed group.> -wrap-foot> aGMT = geometric mean titer.
Enrolled participants were stratified into three groups according to their previous influenza A H5N1 immunization records: participants without priming (control group), participants primed with A/Indonesia/05/2005 vaccine in 2010, and participants primed with A/Vietnam/1194/2004 vaccine in 2008 and A/Indonesia/05/2005 vaccine in 2010.
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