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A phylogenomic analysis using the maximum-likelihood [37] criterion suggested that one of the lancelet (Branchiostoma floridae) inhibin/activin genes is likely to represent an α-subunit orthologue (Figs. 2A, 2B, S2B and S2C), a hypothesis further corroborated by the presence of a specific insertion (Fig. S2B).
Surveillance bias may also explain this finding, as infliximab-treated patients were assessed every 8 weeks before each infliximab infusion: a hypothesis further strengthened by the higher rate of physician-reported events in patients receiving infliximab.
Because of their role in the detoxification of exogenous chemicals present in the diet and the environment, human NAT1 and NAT2 genes have long been considered as likely targets of population-specific selective pressures, a hypothesis further fuelled by the intriguing patterns of geographic differentiation of their major alleles [ 17- 24].
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In order to investigate the redox hypothesis further a biologically less complex, but redox active, quinone (DMNQ) was utilised.
This could be a candidate to investigate the hypothesis further.
Instead of taking months to write and debug a computer simulation of molecular movement, they can instruct the dancers on how to move and see in minutes whether there's a point to investigating that hypothesis further.
A later extension of this hypothesis further posits that the synucleinopathy may even first develop in the enteric nerves in the gut and later spread along the vagus nerve into the brain (Hawkes et al. 2007, 2009).
The work described herein was designed to test this hypothesis further, using an important preclinical toxicology model, the beagle dog.
This reinforces our hypothesis further that an aromatic ring at position 142 is used as an electron acceptor during the catalytic reaction between nitrilase and aliphatic nitriles.
We explored our hypothesis further using an experimental model of trinitrobenzene sulfonic acid (TNBS) -induced chronic pancreatitis in both wild type (WT) and mast cell deficient mice (MCDM).
We then explored our hypothesis further using an experimental model of trinitrobenzene sulfonic acid (TNBS -induced chronic pancreaTNBS -induced wild type and KitW/KitW-v michronictrain deficient in mast cells (MCDM).
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