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However, a human sequence was chosen to represent the HlxB9 gene family because HlxB9 has not yet been recovered in Branchiostoma.
Initially this criterion was used to test the authenticity of an alleged dinosaur sequence [13] which proved to be a human sequence [14].
In principle, we can apply our method to any pair of orthologous sequences, such as a human sequence and the corresponding ortholog in macaque.
The number of unfiltered pairs is low despite a substantial (5%) mismatch rate, because when at least one read within a pair still maps to a human sequence target with more than 97% accuracy the pair is removed.
The remainder of the 14-mers was screened, again with ungapped blastp, against the H. sapiens proteome and those exhibiting strong similarity (Figure S2) to a human sequence were identified as molecular mimicry candidates.
Of these 3,448 (91.1%) hit a human sequence most strongly.
Similar(35)
The capability to detect candidate infectious agents in a human sequencing library was evaluated using spiked-in RNA virus and computational host sequence subtraction.
In contrast, insect HCFs display conserved basic (non-acidic) character without a human-sequence identity, emphasizing an unusual importance of a basic (non-acidic) character for Basic region function.
Dr. O'Neill said they then decided to do a specific search for human contamination by looking for a common human sequence called AluY.
It cost a billion dollars or more 10 years ago to get a complete human sequence.
The V gene was composed of an upper primer-derived sequence (P1), a poly-dG/dC sequence (T1), a human VH sequence, part of the constant gene sequence (T2) and a lower primer-derived sequence (P2).
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