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That was a huge sequence in the storyboards, but George was forced to cut big sections due to time pressures.
This behavior is remarkably similar to what we observe in protein sequence/structure relations (with the sequence playing the role of genotype and the structure of phenotype) where a huge sequence space maps into a much smaller fold space.
Clearly, a population of size 250 (or even several thousand, for that matter) cannot even come close to complete coverage of such a huge sequence space.
This can be due to a huge sequence divergence within the C2 domains family, reflecting the diversity of functions they participate in.
With well over a million Alu-transposons in the human genome, the average distance between two Alus is only 2.4 kb, which suggests that inter-Alu PCR with an enhanced amplicon range coupled to next-generation sequencing could yield a huge sequence subset of the human genome for analysis.
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We do this huge sequence and I had done, last year, The Plaza of Pride where Daenerys' dragons take over the plaza, and this sequence [in episode three] is actually twice as big as that.
Recent advances in NGS technologies have resulted in huge sequence datasets.
Owing to distant relationships and huge sequence dispersion within protein families, it is not always easy to find representative sequences.
We wondered whether absence of these neck proteins was real or due to, once again, the huge sequence divergence.
Thus exploration of huge sequence space by in vitro virus [ 3- 5] or related techniques [ 28, 29] will become possible, depending on the experimental cost.
One may argue that this screening strategy is contentious; however, it allowed us to screen the huge sequence space (Kielak et al. 2013) around the chiA genes that are currently known.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com