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The phrase "a huge problem when" is correct and usable in written English.
It can be used to introduce a situation or condition that causes significant issues or challenges.
Example: "There is a huge problem when deadlines are not met, as it affects the entire project timeline."
Alternatives: "a significant issue when" or "a major concern when".
Exact(11)
The lack of girl-friendly facilities is a huge problem when it comes to menstruation.
The disease was a huge problem when she was a student.
Inaccuracy is a huge problem when companies buy records in bulk — either from the courts or from other companies — and fail to keep them current.
"Zealots are great on the campaign trail," said Julian E. Zelizer, a professor of history and public affairs at Princeton University, "but a huge problem when it comes to governance.
"Zealots are great on the campaign trail," said Julian E. Zelizer, a professor of history and public affairs at Princeton, "but a huge problem when it comes to governance.
"We think anonymity is a huge problem when it comes to comments," he said.
Similar(49)
But they mostly came up dry--a huge problem when oil and gas prices slumped, especially as they were wildly leveraged, with debt levels exceeding assets.
But they mostly came up dry a huge problem when oil and gas prices slumped, especially as they were wildly leveraged, with debt levels exceeding assets.
And of course, the huge problem when you get diagnosed with cancer is that you're not feeling joy, happiness, or really anything positive.
"The overuse of narcotics is a huge problem, and when a patient presents, especially for dental pain, it's difficult to make an objective assessment," she said.
Even in one's professional life, discrimination towards those with mental ill health is a huge problem, especially when it comes to borderline personality disorder.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com