Febuxostat greatly expands the treatment options for refractory or allopurinol-intolerant gout, given the huge prevalence of the disorder and good worldwide availability of only one antihyperuricemic drug.
It is important to note that a huge variability in prevalence rates are detected among studies [ 6].
Previous studies revealed a huge range of prevalence rates, results depending on the survey method, type of substance used for CE and surveyed subjects.
There is a huge variation in prevalence of drinking more than 40 gram alcohol per day (for men, and > 20 g per day for women) across the world, ranging from 0.1% in parts of the Eastern Mediterranean Region to 18.6% in parts of Eastern Europe [ 46].
Water quality is expected to have a huge influence on the prevalence of waterborne diseases.
Other developing countries in Asia that have achieved rapid economic growth have witnessed a huge increase in the prevalence of diabetes.
There is a huge range in reported prevalence rates, due to the fact that the studies are very heterogeneous with respect to the study population (e.g. selection of the study population, country of origin, duration of residence in the country of resettlement, refugee status) and measurement instruments.
In Africa, the prevalence of diabetes has increased significantly and the International Diabetes Federation (IDF) Atlas 2006 reports an overall prevalence of diabetes at 3.1%, affecting a total population of 10.4 million people; a huge number despite a lower prevalence than Europe, 8.4%, and North America, 9.2% [ 1].
And the most plausible explanation for it is the prevalence of a huge informal economy of unregistered and mainly small businesses, in which three Mexicans in five work.
While this is a huge issue when assessing measures of prevalence and incidence (e.g. with respect to pathogen detection), it is well described that a lack of external validity in cohort studies causes less problems since the focus of cohort studies is the investigation of associations within the study population.
