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The phrase "a huge modification of" is correct and usable in written English.
You can use it when you want to express a large change to something, usually in the form of an adjective phrase, such as "a huge modification of the existing system." For example, you might say: "Due to advances in technology, the company implemented a huge modification of their customer service system."
Exact(1)
Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver.
Similar(59)
The presence of a huge number of modifications, however, indicates that this method is highly unstable and still awaits improvements.
This modification of inclusion criteria led to a huge increase of up-regulated genes.
With the advancement of next-generation sequencing technologies, researchers are now able to generate a huge amount of data of various biological features of interest, including ChIP data for multiple transcription factors, histone modifications, nucleosome positioning and RNA-seq.
It was a huge leap of faith.
"There was a huge industry of corruption".
"Saturn is a huge favorite of mine".
It's a huge piece of business.
Coaches deserve a huge amount of credit.
"That's a huge part of winning.
Fun is a huge part of it.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com