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The phrase "a huge difference to him" is correct and usable in written English.
It can be used when discussing the impact or significance of something on a person's life or feelings.
Example: "The support from his friends made a huge difference to him during tough times."
Alternatives: "a significant impact on him" or "a major change for him."
Exact(1)
This would have made a huge difference to him - it would have meant he didn't have to be on dialysis.
Similar(59)
That makes a huge difference to people.
Luck made a huge difference to me.
Made a huge difference to women.
That's a huge difference". It's made a huge difference to Joe Caccio.
That made a huge difference to us".
"Even for somebody who was working, £20,000 is a hell of a lot of money, so it will make a huge amount of difference to him".
"I know the manager was very keen to have Nicky back, that makes a huge difference and so good luck to him once again".
A huge difference".
Hardly a huge difference.
"It made a huge difference.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com