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The phrase "a huge clinical problem" is correct and usable in written English.
It can be used when discussing significant issues or challenges faced in a clinical or medical context.
Example: "The rise of antibiotic resistance has become a huge clinical problem for healthcare providers worldwide."
Alternatives: "a major clinical issue" or "a significant clinical challenge".
Exact(4)
Third, suicide is a huge clinical problem.
Hemodialysis vascular access dysfunction currently is a huge clinical problem.
Given the widespread occurrence of coronary atherosclerosis in the human, myocardial ischemia is a huge clinical problem.
Lung cancer is a leading cause of cancer-related death worldwide, and the morbidity and the mortality rates are similar, which is a huge clinical problem [ 20].
Similar(56)
Lack of confirmation in various patients also poses a huge problem in the clinical application of mass spectrometry and microarray data to identifying disease-specific biomarkers [ 12, 13].
This is a huge health problem.
This is a huge, complex problem.
China has a huge pollution problem.
It's a huge, huge problem.
It was a huge, huge problem, and it's still there.
Overconfidence is a huge behavior problem for investors.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com