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A similar process has been observed for gene regulatory networks, with transcription factors-the key organizers of the genes transcriptional activity-being preferentially lost during the adaptation to a host-associated lifestyle [ 30].
Many of them have been shown to be important members of their given ecosystems and to play crucial roles in various environmental and host-associated biological processes.
This metacommunity forms the regional pool of prokaryote species from which local (within a single host) host-associated communities of microorganisms are assembled.
This may be explained by the fact that these organisms are host associated: it is known that host-associated bacteria tend to undergo a genome reducing process.
Reductive evolution is the process whereby host-associated consorts decrease their genome size by abandoning genes that are needed by free-living microorganisms but that are dispensable when living in association if essential gene products are readily available from the host or from other symbiotic partners.
In order to analyze the microevolutionary processes in host-associated microorganisms, we simulated the dynamics of rhizobia populations composed of a parental strain and its mutants possessing the altered fitness within "plant-soil" system.
Lactobacillus crispatus is a ubiquitous micro-organism encountered in a wide range of host-associated habitats.
In the present study, we used LLC (Lewis lung carcinoma) cells with mPGES-1 knockdown or overexpression, as well as mPGES-1-deficient mice to examine the roles of cancer cell- and host-associated mPGES-1 in the processes of tumorigenesis in vitro and in vivo.
Here we interrogate the hypothetical proteomes of prokaryotes, constructed from their published genomes, to profile the universality of the shikimic acid pathway with a view to understanding a key metabolic process of free-living and host-associated bacteria.
Collectively this work provides novel insights into the evolution of commensal and pathogenic lifestyles within a single clade of host-associated bacteria.
Our findings indicate that host genetics are part of a complex web of host-associated factors influencing microbiome composition.
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