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The implications of these findings for host specificity testing depend largely on the specific aims of a host range assessment.
Interestingly BPV-14 has not been detected in any equine sarcoid suggesting that BPV-14 has a host range that is limited to bovids and felids.
We conclude that P4 is a host range determinant and a target for modifying the productive infection potential of the virus - an important consideration in adapting these viruses for oncotherapy.
This suggests that a host range selection of mutations was probably not involved.
S. Gallinarum has a host range restricted to birds and causes a severe systemic disease called fowl typhoid.
In contrast to neutral glycans, Sia with a negative charge is a major receptor and a host range determinant of influenza viruses [25].
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LSDV has a host-range restricted to ruminants and is currently being investigated as an HIV vaccine vector [ 3, 56].
One extreme example for this is Trypanosoma b. rhodesiense, which is human-infective and thought to be a host-range variant of T. b. brucei.
In some assays the marked competitor was a host-range mutant containing a substitution in gene P3 of the medium RNA segment, allowing infection of P. pseudoalcaligenes bacteria.
Using published methods [ 29] we assayed fitness on PP, as well as on ERA if the test phage contained a host-range mutation.
The introduction of V. inaequalis in Europe was followed by a host-range expansion from M. × domestica to the more phylogenetically distant M. sylvestris.
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