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Finally, a single-residue substitution of D510A that disrupts its salt-bridge interaction with DPP4 R317, or a change of E513A that disrupts its hydrogen-bonding interaction with DPP4 Q344, also hindered, to variable degrees, both binding and viral entry; while the impact of other mutations such as R511A was not significant.
Diagnosis of these conditions can be hindered by variable penetrance and the presence of non-specific clinical or pathological features.
Isothermal kinetic results were obtained for reactions between aromatic diamines with variable steric hindrance and two bismaleimide monomers, one with a structure hindered a from the two maleimide functions (BMEt) and the other not (BM).
Is it helping or hindering the output variables (quality, yield, etc).? Under what conditions does this occur?
In general terms, a misclassified confounding variable hinders the ability to control confounding.
Heavy snowfalls can severely hinder transporation in variable moderate climates but provides a firm surface for travel in remote Arctic, Antarctic, and mountainous areas, using traditional dogsleds or snowshoes or modern snowmobiles.
"That probably did a lot of hindering, working all around".
This political argument is hindering a fair and principled solution.
He also denied hindering a police investigation into the case.
In addition, an accurate estimate of the burden of post-operative AKI has been hindered by the variable definitions applied to diagnosis AKI.
Despite the noticeable advances in this approach, a number of confounding variables are still hindering the introduction of metabolomics for full clinical application.
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