This was most clearly seen in the pivotal clinical trial of trastuzumab in HER2-positive metastatic disease in which only 145 patients were needed to show both a highly significant progression-free survival and overall survival benefit for the addition of the monoclonal antibody to paclitaxel chemotherapy as first-line therapy [ 4].
Combining ANXA10 and p53 expression resulted in a highly significant prediction of progression (P<0.00001, log rank test; Figure 1C).
In a bivariate Cox model, [(18 F]FDG-PET positivity after chemotherapy remained a highly significant predictor of progression-free survival even after controlling for bulky disease and International Prognostic Score more than 2.These data indicate that PET status after chemotherapy is strongly predictive of FFP with the Stanford V regimen despite the use of consolidative radiotherapy.
When cases with either TP53 mutation (L2/L3 type) or GMP+ were combined, there was a highly significant association with disease progression (PD) (P=0.001).
CA125 was a highly significant predictor of both progression free and overall survival after the first cycle and throughout primary chemotherapy.
However, in the statistical analysis adjusted with baseline Larsen score, a highly significant difference in radiologic progression was found between the groups.
Robust statistical analyses at various time points of arthritis progression showed a highly significant correlation to histopathological inflammation assessment, proposing F-FDG small-animal PET/CT as a feasible tool for preclinical arthritis research.
These observations were subsequently quantified revealing a highly significant correlation of DPEP1 expression and CRC progression (P<0.0001, chi-square test; Figure 4C).
A highly significant overrepresentation of genes involved in cell cycle progression was observed in the GO-term analysis.
In a 3-year follow-up, van Leeuwen et al. [ 63] demonstrated a highly significant correlation between time integrated CRP values and radiographic progression of disease in patients with newly diagnosed RA.
Figure 3 shows the two most differentially expressed snoRNAs, both showing a highly significant (p < 0.01, ANOVA and Tukey's post-test) incremental increase in expression through progression from normal prostate to localized and then metastatic PCa samples.
