The phrase "a highly significant hit" is correct and usable in written English.
It can be used in contexts where you want to emphasize the importance or impact of a particular event, finding, or result.
Example: "The research team reported a highly significant hit in their latest experiment, which could lead to groundbreaking discoveries."
Alternatives: "a major breakthrough" or "a crucial finding".
The ULBP1 gene itself was a highly significant hit, providing a validation of this approach.
A highly significant hit was obtained spanning the fungal full-length protein sequence (Additional file 1: Figure S2A).
Although BLASTP searches [ 19] seeded with the TP1 sequence also failed to identify homologs in public databases, more sensitive Hidden Markov model-based HHpred analysis [ 20] resulted in a highly significant hit.
The program identified two genomic regions, one from each organism, that gave a highly significant hit (e-value < 1 × 10-14) against a mariner transposase from Drosophila melanogaster (gi1006789 in Fig. 3A).
In an attempt to gain a further insight into these possibilities, from the 20 unique sequences with the longest predicted reading frames we inspected more closely the sequences that had a highly significant "hit" to another insect protein (BLASTX, <1e-20) (Table 3).
When the BLAST of a given EST sequence search had highly significant hits on multiple RefSeq protein IDs, we found they were generally isoforms of the same gene.
If a protein showed a highly significant correlation ("hit") to a single HMM profile, this was used to create a "trusted" annotation of the sequence.
The slightly down-regulated unigene8445 and 752 had a highly significant BLAST hit to the Na+/H+ antiporter of M. crystallinum and the NHX1 of Tetragonia tetragonioides, respectively.
In order to test this assumption, we determined the representation of previously characterized pea repeats in the 454 data by sequence similarity searches against a database of individual sequence reads and calculated their average coverage by highly significant hits.
However, all 11 had highly significant hits to proteins in NR.
For many of these proteins there were two or more highly significant hits to established HMM profiles.
