Sentence examples for a highly sensitive methodology from inspiring English sources

In order to understand the incidence and clonal dynamics of pre-leukemic clonal hemopoiesis, we interrogated 15 leukemia-associated mutation hot spots using a highly sensitive methodology able to detect small clones with mutations.

The number of mutant ACH molecules (c.1138G>A) was assessed by a highly sensitive methodology based on the amplification of millions of single DNA molecules with BEA (27, 29), followed by genotyping individual beads with previously developed methods (26, 28).

Most of the published PCR protocols for identification of transgenes in papayas have relied on tissues of individual plants or seeds derived from homogeneous populations [ 24, 27], leaving unresolved the complications inherent in developing an accurate, highly sensitive methodology for detecting and quantifying the presence of transgenes in a mixture of GE and non-GE sources.

In this work, a simple and highly sensitive methodology for the analysis of synthetic musk fragrances in indoor air samples is presented.

Furthermore, this method has a total analysis time of less than 1 min. Melatonin concentrations are significantly higher in samples obtained from dark conditions, consistent with previous results, and thus proving that MALDI-MSI is a suitable, simple, and highly sensitive methodology for direct melatonin analysis from complex biological samples.

Because of the high fatality rate and damaging effects resulting from untreated meningitis in rural high-poverty areas, a simple, low-cost, highly sensitive methodology is in great need for the immediate and early diagnosis of meningitis.

Our findings suggest that previous reports may have overestimated the frequency of significant methylation events with the use of non-quantitative but highly sensitive methodology.

Furthermore, gel electrophoresis of products demonstrated similar sized bands for insignificant levels of methylation as well as unamplified DNA, emphasizing the limitations of non-quantitative but highly sensitive methodology.

All the sperm samples were procured from the buffalo in-vitro fertilization (IVF) center where utmost care was taken to avoid the diploid cell contaminations in the sperm preparations using highly sensitive methodologies and modern techniques.

A highly sensitive, specific and high-throughput methodology was additionally implemented to confirm and quantify most dramatic molecular changes taking place in urine and here identified, as predictor markers of albuminuria progression, both in diabetics and non-diabetics.

Here, we report the development of a highly sensitive capillary size exclusion chromatography (SEC) methodology for Fab aggregate analysis in HVH.