Sentence examples for a highly deleterious from inspiring English sources

MG can also inhibit the activity of GAPDH (Lee et al. 2005), causing triose phosphate accumulation and thereby increasing MG generation, and so inducing a highly deleterious cycle.

Cell viability after miRNA transfection varied extensively, however especially knock in of miR-138 and miR-886-3p miR-886-3p miR-886-3pous effect on cell viability in hadf of the analyzed cell lines.

Given the inevitable translation that these discoveries will have to clinical practice, being able to distinguish between a highly deleterious de novo dominant mutation and a silent heterozygous recessive mutation is invaluable for clinical management and family planning decisions.

Compound heterozygotes for CFTR mutations comprising a highly deleterious mutation on one allele (such as p.F508del) and a less severe mutation on the other allele (such as intron 8 5T) have long been known to display an increased risk of ICP (reviewed by Chen and Férec).

Given the rarity of large drops in fitness, the most parsimonious explanation is that each one of these drops was driven by a single highly deleterious mutation.

In conclusion, we find that fitness decays in recurrently bottlenecked populations of hypermutator P. aeruginosa because of the fixation of many weakly deleterious mutations and a few highly deleterious mutations.

36 However, Hietpas et al. 37 report a clear bimodal DFE of mutations, comprising a set of nearly neutral mutations and a set of highly deleterious mutations; in fact, a closer look indicates that many site-directed mutagenesis studies reporting Γ-like DFE of mutations do actually see bimodal DFE if they include the set of lethal mutations.

For example, a small number of highly deleterious mutations have been identified in the nuclear genes encoding protein components of mitoribosomes, mitochondrial translation factors and elements of the apparatus involved in the maturation of mitoribosomes (13– 20).

Although our results on nearly neutral and advantageous mutations and substitutions roughly correspond to previous results obtained with evolution-based methods, we observe a large fraction of highly deleterious mutations (S < −10), better matching the number of experimentally observed lethal mutations.

First, most mutations carry little, if any, fitness cost in a laboratory environment, but a substantial fraction of mutations are highly deleterious.

In addition, defective mitochondria, which can be highly deleterious to a cell because of their output of reactive oxygen species, need to be repaired by fusing with healthy mitochondria or cleared from the cell.