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The major hurdle with this approach is the difficulty of fabricating scale-up tissues without using a mold support as the mold structure restricts the cell pellet into a highly confined space25,26.
In TERS, the metal tip is illuminated by a laser to create a highly confined hotspot at its apex, from which the SERS spectrum of a molecule can be measured.
Then, once the tumor cells receive this "go" signal, the researchers want to find out precisely how these runaway cells escape through a highly confined area of bone and tissue and travel toward nearby blood vessels to hitch a ride to another part of the body.
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When the solvated ions enter sub-nanometer pores, their hydration shells are partially or completely stripped, reducing their effective diameter and inducing more charges accommodated inside a single highly confined pore with a fixed volume.
It shows that an intense optical field was developed at the apex of the probe tip and the local field was highly confined to a tiny volume near the apex.
Such random migration is highly confined to a fixed spatial region surrounding the point of adhesion and does not show the long-range directed migration visualised in vivo, but it still displays formation of a biased lamellipodium in the direction of cell motion and moderate displacement of the cell body (supplementary material Movie 3).
Potterat says, "For years, syphilis had been confined to a specific region of Baltimore, within highly confined socio-sexual networks.
Van Laer, R., Kuyken, B., Van Thourhout, D. & Baets, R. Interaction between light and highly confined hypersound in a silicon photonic nanowire.
However, because the bluff-body is highly confined (typically in a pipe) the shed vortices may interact with the pipe wall; causing an undesirable non-linear behaviour.
(Error - same as 91) D. A. B. Miller and D. S. Chemla, "Electroabsorption of highly confined systems: Theory of the quantum-confined Franz-Keldysh effect in semiconductor quantum wires and dots," Appl.
D. A. B. Miller, D. S. Chemla, and S. Schmitt-Rink, "Electroabsorption of highly confined systems: Theory of the quantum-confined Franz-Keldysh effect in semiconductor quantum wires and dots," Appl.
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